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KMID : 1134819990280040901
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Journal of the Korean Society of Food Science and Nutrition
1999 Volume.28 No. 4 p.901 ~ p.906
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Effects of Extract of Pueraria radix on Lipid Peroxidation in Ethanol - Administered Rats
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Lee Jeong-Sook
Kim Eun-Sil
Kim Seck-Hwan
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Abstract
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This study was designed to investigate the effect of Pueraria radix extract on lipid peroxidation in ethanol administered rats. Male sprague-dawley rats were given 25% ethanol(2.5g per Kg body weight; E), 10% pueraria radix extract(CP), 25% ethanol and 10% pueraria radix extract(EP). The activity of hepatic superoxide dismutase was increased by ethanol and was lower in the EP group than in the E group. Hepatic catalase activity was increased by ethanol, but decreased by Pueraria radix extract. E group rats had significantly higher liver glutathione peroxidase activity. Activity of hepatic glutathione S-transferase was higher in the CP group than in the other groups. No significant differences was found in liver glutathione and lipid peroxide contents between control and EP group. These data indicate that the peroxidative damage associated with chronic ethanol consumption might be decreased by Pueraria radix extract.
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KEYWORD
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lipid peroxidation, Pueraria radix, ethanol
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